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Category: LCMS


Shimadzu Scientific Instruments introduced the LCMS-9050, a quadrupole Time-of-Flight (Q-TOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models.

The LCMS 9050 provides the highest mass accuracy levels available and fast polarity switching. Shimadzu’s proprietary high precision temperature control system inhibits even tiny mass variations caused by external factors, so that the system can be used to measure accurate mass values without worrying about mass calibration.

The stable positive/negative high-speed polarity switching technology enables the simultaneous analysis of positive ions/negative ions, contributing to new applications development and heightened analysis efficiency. To ensure that all users can perform analysis easily and efficiently, Shimadzu has aimed to simplify mass calibration, maintenance, and other non-analysis procedures. Further, combining this system with Shimadzu’s renowned lineup of varied optional equipment enables greater utilization of the characteristics of Q-TOF while greatly expanding the range of data obtainable.


Simpler Accurate Mass Spectrometry
With technologies inherited from the Shimadzu LCMS series, the 9050 can maintain stable long-term mass accuracy.  The system includes an auto-tuning function that uses a standard sample to automatically adjust mass accuracy, resolution, sensitivity, and other parameters.

Provides High-Speed Polarity Switching Even with TOF

The LCMS-9050 provides high-speed polarity switching by substantially shortening the time required for stabilization standby during polarity switching. With the LCMS-9050, stable mass accuracy is shown even during high-speed positive/negative polarity switching, enabling simultaneous positive ion/negative ion analysis.

Accommodates a Variety of Needs

The LCMS-9050 is designed so that a variety of optional devices can be connected. The ESI ionization unit included as standard can easily be replaced with a DPiMS™ probe electrospray ionization unit. In addition, the Q-TOF can be combined with the CLAM™ fully automatic LCMS pretreatment unit, the Nexera Mikros™ micro flowrate system, and the Nexera™ UC supercritical fluid extraction (SFE)/supercritical fluid chromatography (SFC) system.

Learn more about the LCMS 9050 Here


Written and Published by Mitchelle Gacheri


Liquid chromatography (LC) separates the components of a sample based on the differences in their affinity/retention strength during the stationary phase and mobile phase. Common LC techniques, namely reversed-phase, normal phase, and size exclusion chromatography. With technological advancements the LC has evolved to analyze smaller particle sizes and higher pressure that are more efficient, have higher speed, sensitivity, and resolution. This includes the high-performance liquid chromatography (HPLC) and the ultrahigh-performance liquid chromatography (UHPLC).

Upon separation by LC, the components can be detected using optical properties such as ultraviolet-visible (UV-VIS), fluorescence, refractive index, evaporative light scattering, or electrical conductivity based on the analytes’ properties. When the analyte passes through the detector, a change (e.g., increase or decrease) in the optical property will be observed and recorded.

Chromatograms obtained using these optical detectors primarily identify or qualify substances based on the retention time and quantitate substances based on the peak area and intensity. The LC chromatogram shows an example of a typical chromatogram obtained using these optical detectors. LC coupled with optical detection offers great quantitative accuracy for analytes that can be chromatographically resolved, where a detected peak comprises only a single component. However, achieving required resolution is challenging for complex samples where multiple components elute approximately at the same time. In contrast, mass spectrometry (MS) offers a highly sensitive detection technique that ionizes the sample components, separates the resulting ions in vacuum based on their mass-to-charge ratios (m/z), and measures the intensity of each ion. A mass spectrum plots the relative ion intensities against the m/z values, and a series of mass spectra are generated at each time point. This information indicates the concentration level of ions that have a given mass and is extremely valuable for the unique identification of molecules, also known as qualitative analysis. Moreover, MS provides added specificity and sensitivity, and the convenience of simultaneous multicomponent analysis.


When the LC is coupled with MS, the mass spectra obtained from these measurements provide molecular mass and structural information for eluted components, which supplement the qualitative information based on retention times obtained using other LC detectors. Therefore, LCMS combine the outstanding separation resolution of LC with the excellent qualitative capabilities of MS.

With its superior qualitative and quantitative capabilities and robustness, LCMS is commonly used to meet the rigorous demands of the analytical market and industries. LCMS is applied in many industries such as pharmaceuticals, biopharmaceuticals, forensic, industrial, food and environmental sector. For clinical research, the analysis of drugs, vitamins and minerals in whole blood, plasma, serum and urine is conducted routinely using LCMS. It is also applied in metabolomics, proteomics and genomics study. The use of LCMS in the biopharmaceutical discipline have enabled the bioanalysis and characterization of antibody drugs.


In the environmental field, LCMS is widely utilized for the qualitative and quantitative determination of known pollutants (e.g. pesticides, bacteria, pharmaceuticals and personal care products) and trace-level emerging contaminants. Food safety and development have also adopted the use of LCMS in their product quality control such as the quantitation of residual veterinary drugs, food additives and the composition analysis of supplements and organic foods. With high sensitivity, high detection selectivity and high qualitative capability, MS bring about the flexibility of simultaneous multi-component analysis, improved productivity, and efficiency to HPLC analyses in these applications.


Written By Steven Kuria – Sales Executive ESTEC Ltd 
Published By Mitchelle Gacheri – Marketing Executive ESTEC Ltd 


Glyphosate and Glufosinate are phytosanitary products widely used as weed killers, especially in cereal and vegetable crops. This study presents a new analytical approach allowing their quantification and separation on reverse phase thanks to in-vial -addition of a pairing agent. This new strategy provides a method that allows to achieve good retention, separation, and sensibility. A rapid method is set up with 7 min run and easy sample preparation. This sensitivity allows their quantification below 50 µg/kg for fruits and 100 µg/kg whatever the matrix. This method shows good repeatability, yield extraction, and robustness.

#innovation #shimadzu #foodandbeverage #pesticideAnaysis #foodsafety #glyphosate #glufosinate